Ramesh Mendola is considered to be a close associate of national General Secretary of the Bharatiya Janata Party Kailash Vijayvargiya, who is also from Indore and originally represented Indore-2 constituency until handing it over to Mendola in 2008.
Before fighting assembly election, Mendola has been previously elected as a corporator in Indore Municipal Corporation several times. He has also served as the city President of Indore BJP. He has also served as the president of Nanda Nagar Sakh Sahkari Sanstha Maryadit, a local credit cooperative society in Indore-2, his constituency. Ramesh Mendola was elected to the Vidhan Sabha in 2008, 2013 and 2018.